NT5E and neoplasm: In detail, for gastric cancer patients, CD73 may serve as a regulator in RICS/RhoA-LIMK-cofilin signaling pathway by its extracellular function in adenosinergic pathway, and then promote β-catenin-induced epithelial-mesenchymal transition (EMT) process, which is correlated with metastasis property of tumor cells (Xu et al., 2020; Goulioumis and Gyftopoulos, 2022).