Protective cardiovascular effects of kaempferol through activation of the Nrf2 pathway have been demonstrated in numerous animal models, including ISO-induced HF in diabetic rats (L. Zhang et al., 2019), HFD-induced AS in APOE−/− mice (Feng et al., 2021), STZ-induced DCM in mice (X. Chen et al., 2018), and LAD induced MIRI (D. Wang et al., 2017) (Table 2). This evidence concerns the gene NFE2L2 and familial dilated cardiomyopathy.