HMOX1 and myocardial infarction: In an LAD-induced MI model, isoliquiritigenin (ISL) or icariin significantly reduced the myocardial infarction area, improved cardiac function, inhibited ROS and MDA production, suppressed SOD and GPx consumption through increased nuclear Nrf2 and cytosolic HO-1 levels and reduced OS after AMI (Sai et al., 2022; D. Yao et al., 2022).