NFE2L2 and endothelial dysfunction: Diosmetin is a citrus flavonoid that improves endothelial dysfunction, suppresses over activity of sympathetic nerve-mediated vasoconstriction and upregulates Nrf2 and HO-1 proteins in Nω-nitro-l-arginine methyl ester l-NAME-induced HTN rats (Meephat et al., 2021).