Cardamonin, a flavone compound naturally residing in multiple herbs, such as Alpinia katsumadai, Ginkgo biloba, and Carya cathayensis Sarg, under conditions of LPS-induced HF or DOX-induced cardiotoxicity, effectively inhibited cardiac mechanical dysfunction and OS through promoting nuclear translocation of Nrf2 along with increasing HO-1 and antioxidant defense, which were reversed upon intervention with a Nrf2 inhibitor (Qi et al., 2020; Y. Tan et al., 2021). The gene discussed is HMOX1; the disease is hydrops fetalis.