Moreover, astragaloside IV has been shown to exert potent cardioprotective effects in various animal models, including abdominal aortic constriction (AB)-induced HF, LAD-induced HF and MIRI, through activation of Nrf2/HO-1 signaling (M. Jiang et al., 2019; Nie et al., 2019; Sui et al., 2020). This evidence concerns the gene HMOX1 and hydrops fetalis.