One migraine treatment target that has attracted great attention is the calcitonin gene-related peptide (CGRP)-mediated CLR/RAMP1 receptor (i.e., the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) complex) signaling (Tso and Goadsby, 2017; Kumar et al., 2022). Here, RAMP1 is linked to migraine disorder.