In addition to CGRP, ADM has been implicated in the regulation of inflammatory heat hyperalgesia, the development of morphine tolerance, and spinal glial activation as well as migraine pain (Ma et al., 2006; Fernandez et al., 2010; Wang et al., 2011; Zeng et al., 2014; Ghanizada et al., 2021; Garelja and Hay, 2022; Rees et al., 2022). Here, ADM is linked to migraine disorder.