Pyroptosis is a form of RCD; when cells are stimulated, aspartate-specific cysteine-containing proteases (Caspase) can be activated by the intracellular inflammasome, which cleaves Gasdermin (GSDM) protein family to form the plasma membrane pores, causing inflammatory cell death, which is of great significance in cancer and cancer treatment [9]. The gene discussed is GSDMA; the disease is cancer.