SCAF11 (3%), NLRP7 (3%), NLRP2 (3%), CASP5 (2%), PLCG1 (2%), NLRP3 (2%), CASP1 (2%), CASP8 (2%), GSDMC (1%), NOD1 (1%), CASP9 (1%), ELANE (1%), GSDMD (1%), NLRC4 (1%), NLRP6 (1%), NOD2 (1%), and NLRP1 (1%) occurred somatic mutations as well as most of them had high frequencies of CNV in BLCA. The gene discussed is NLRP3; the disease is bladder transitional cell carcinoma.