On the other hand, a large number of hypercoagulable states have been associated with LV, including antiphospholipid antibodies, factor V Leiden mutation, protein C and S deficiency, prothrombin mutation, antithrombin III deficiency, hyperhomocysteinemia, and increased levels of lipoprotein(a) (4, 8, 12). The gene discussed is F5; the disease is hyperinsulinemic hypoglycemia, familial, 4.