It can be seen that 17 major cluster labels were marked, including osteosarcopenia, irisin, calcium, peripheral quantitative computed tomography, accelerometer, sarcopenia, microgravity, vitamin d supplementation, whole body vibration, biochemical markers of bone turnover, obesity, sclerostin, older men, body mass, juvenile idiopathic arthritis, bulimia and male athlete triad. The gene discussed is FNDC5; the disease is obesity due to melanocortin 4 receptor deficiency.