VEGF-A, VEGF-C, and VEGF-D are the ligands of VEGFR2 and regulate angiogenesis, vasculogenesis and vascular permeability, whereas binding of VEGF-C and VEGF-D to VEGFR3 controls lymphangiogenesis and plays a key role in tumor metastasis via lymphatic vessels (4, 5). This evidence concerns the gene KDR and neoplasm.