The APASL proposed the diagnostic criteria for ACLF based on the expert consensus (5): “In patients with or without previously diagnosed chronic liver disease, acute liver injury is followed by jaundice [total bilirubin (TBil) >50 mg/L (>85.5 μmol/L)] and coagulopathy [international normalized ratio (INR) >1.5 or prothrombin activity <40%], with ascites and/or hepatic encephalopathy within 4 weeks of onset.” The definition of ACLF in APASL focuses on liver failure. The gene discussed is F2; the disease is Hepatic failure.