Previous study in our laboratory showed that dietary supplementation of pectin could enhance intestinal barrier function (Wen et al., 2022), increase the expression of Claudin-4 and Muc-2 in the cecum of piglets (Wu et al., 2020), and abolish the abnormal expression of ZO-1 and Occludin caused in the acute pancreatitis model (Xiong et al., 2021). This evidence concerns the gene MUC2 and acute pancreatitis.