For the rs4494157 variant, it has been associated with an increased susceptibility to rheumatic fever with or without rheumatic heart disease (allele A = OR: 2.93, p value: 0.0002 and OR = 2.23, p value = 0.008, respectively) [25], and the +1637delC variant, involving a heterozygous deletion state in the gene and consequent ficolin-3 deficiency, was associated with an increased risk of developing the disease (OR: 8.0; 95% CI 1.01-63.0; p value < 0.05%) [26]. This evidence concerns the gene FCN3 and rheumatic heart disease.