When apolipoprotein B concentration quartiles were classified, there was a significant positive correlation only in the Q4 interval (OR: 2.011; 95% CI: 1.238, 3.267; p = 0.005), and each unit increase in serum apolipoprotein B concentration was associated with a 101% increased risk of osteopenia or osteoporosis. The gene discussed is APOB; the disease is Osteopenia.