Therefore, it is essential to investigate new biomarkers of bone health, such as serum apolipoprotein B. In previous studies, obesity lead to an increase in bone mineral density because of the higher mechanical load, which may contribute in protecting the bone (Gkastaris et al., 2020; Qiao et al., 2020). The gene discussed is APOB; the disease is obesity due to melanocortin 4 receptor deficiency.