Elevated obesity (weight overload) leads to elevated levels of apolipoprotein B in the blood (Manapurath et al., 2022), which decrease with exercise, vegetarianism, and hypolipidemia (Hostmark et al., 1993; Gao et al., 2018; Stanton et al., 2022). Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.