CASP3 and infection: The analysis showed that the infection-induced increase in NE permeability was partially reversed upon exposure to the inhibitors (Figure 2B), leading to significantly increased fluorescence half-life in the nucleus from 39 ± 3 s to 55 ± 5 s (p < 0.01) and 66 ± 6 s (p < 0.001) for Cdk1 inhibitor and caspase 3 inhibitor, respectively.