While no homozygous embryos were detected beyond E10.5 (Hurd et al., 2007; Layman et al., 2010; Yan et al., 2020), the heterozygous Chd7 mice recapitulate various symptoms of CHARGE syndrome, such as coloboma, inner ear abnormalities, cleft palate, choanal defects, cardiovascular defects, genital defects, and developmental growth delays (Bosman et al., 2005; Layman et al., 2009; Layman et al., 2010; Schulz et al., 2014b; Ogier et al., 2014; Gage et al., 2015). The gene discussed is CHD7; the disease is CHARGE syndrome.