RAC3 and epilepsy: Mice with both Rac-N and Rac3 null mutations show defective migration and maturation of cortical and hippocampal inhibitory neurons, severe neurological and cognitive deficits, and spontaneous epilepsy, while the single disruption of Rac3 does not cause evident defects (Corbetta et al., 2008, 2009; Pennucci et al., 2011; Vaghi et al., 2014).