It has been shown that damage in the dendritic tree of CALB2-positive neurons may result in impaired synchronization of the entire interneuron network responsible for dendritic inhibition, resulting in an asynchronous, thus less effective, inhibition of principal cells, which may be involved in epilepsy onset (Tóth and Maglóczky, 2014). Here, CALB2 is linked to epilepsy.