Mutations in the human nectin-1 gene are responsible for cleft lip/palate ectodermal dysplasia, Margarita Island ectodermal dysplasia, and Zlotogora–Ogür syndrome, which is characterized by cleft lip/palate, syndactyly, intellectual disability, ectodermal dysplasia, and partial deafness (Bustos et al., 1991; Suzuki et al., 2000; Sozen et al., 2001). The gene discussed is NECTIN1; the disease is ectodermal dysplasia syndrome.