TRPV4 and ischemia: The role of TRPV4 in the brain edema formation was reported in the TRPV4–/– animals, where TRPV4 deficiency led to the reduction of cell swelling and amelioration of peri-infarct depolarization (Jie et al., 2015; Rakers et al., 2017; Hoshi et al., 2018), as well as to the decrease in ischemia-induced lesion volume and milder neurological symptoms (Tanaka et al., 2020).