A similar difference between the TRPV4–/– and AQP4–/– animals was seen in the rodent stroke model, where the deletion of TRPV4 ameliorated peri-infarct depolarization (reduced influx of Ca2+ and lower extracellular accumulation of glutamate), however, the deletion of AQP4 did not have a similar effect (Rakers et al., 2017). This evidence concerns the gene AQP4 and stroke disorder.