AQP4 and ischemia: Contradictory to the findings that detected slower changes of brain diffusivity in AQP4–/– during acute ischemia in vivo (Yao et al., 2015; Hirt et al., 2017; Chmelova et al., 2019), we did not observe a similar influence of AQP4 deletion during OGD in situ (Chmelova et al., 2019).