AQP4 and meningioma: This response of the AQP4–/–/TRPV4–/– mice to pMCAO indicates an interplay between these two channels, which was previously suggested in the experiments using cultured glia (Benfenati et al., 2011; Jo et al., 2015; Redmon et al., 2021) or in meningiomas (Faropoulos et al., 2021), where AQP4-mediated water fluxes promote the activation of TRPV4, whereas Ca2+ entry through TRPV4 channels reciprocally modulates volume regulation, swelling, and Aqp4 gene expression (Jo et al., 2015).