A recent study showed that both p21WAF1/CIP1 and p16INK4a were expressed by astrocyte and induced senescence state in early stages of the and amyotrophic lateral sclerosis, whereas p21WAF1/CIP1 was exclusively expressed by neurons and might reflect a more general mechanism of age-related cell-cycle dysregulation (Vazquez-Villaseñor et al., 2020). Here, CDKN1A is linked to amyotrophic lateral sclerosis.