A lower CC was proposed to be an independent factor for physical performance [Short Physical Performance Battery (SPPB) score: 7.27 vs. 6.18, p = 0.02] and muscle strength (hand grip: 32 vs. 28 kg, p = 0.03) measures even after adjustment for potential confounders, including age, sex, education, body mass index, sensory impairments, cerebrovascular diseases, albumin, C-reactive protein, interleukin-6, and cholesterol, based on a study in a population of persons aged ≥80 years enrolled in Sirente, Italy (31). Here, IL6 is linked to cerebrovascular disorder.