On the other hand, by lowering the level of ACE2, the ACE2/Ang (1–7)/Mas receptor pathway will be inhibited, breaking the balance of renin angiotensin aldosterone system (RAAS), which is not conducive to the maintenance of hemodynamic stability and normal cardiorenal function, and may induce acute myocardial injury, ACS, arrhythmia, and HF, leading to increased mortality of COVID-19 patients (45, 85). The gene discussed is ANGPT1; the disease is injury.