Some groups investigated the upstream of SYK in hepatocellular carcinoma, and the results indicated that SYK can be regulated by checkpoint kinase 1 (CHK1) effectively, and the phosphorylation of SYK induced by CHK1 enhances the subsequent proteasomal degradation of SYK in hepatocellular carcinoma [62]. The gene discussed is CHEK1; the disease is hepatocellular carcinoma.