SYK and hepatitis A virus infection: In virus infection-induced hepatitis, scientists have confirmed that the expression of SYK and cytokines in hepatocytes can be significantly upregulated by Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV) infection, and the increased cytokines and SYK expression in hepatocytes further enhance the transcription of fibrosis-related genes in hepatic stellate cells (HSCs), the core participants in liver fibrosis [7].