Recently, researchers revealed that SYK enhances the activation of HSCs via facilitating the generation of reactive oxygen species (ROS) and autophagy in liver, and the combinational application of Silybin (ROS inhibitor) and GS-9973 (SYK inhibitor) hold promising therapeutic action against mouse liver fibrosis and liver cirrhosis [56]. The gene discussed is SYK; the disease is cirrhosis of liver.