VIRSTA score included 10 parameters (cerebral or peripheral emboli, meningitis, vertebral osteomyelitis, permanent intracardiac device or previous IE, pre-existing native valve disease, intravenous drug use, prolonged bacteremia for 48 h, community or non-nosocomial healthcare-associated bacteremia, severe sepsis or shock, and C-reactive protein >190 mg/L) with each parameter ranging from 1 to 5 points (8). This evidence concerns the gene CRP and bacterial infectious disease with sepsis.