MAPK7 and atherosclerosis: In blood flow low shear stress or oscillatory shear stress (atherosclerosis susceptible area), endothelial protective mitogen activated protein kinase 7 (MAPK7) signaling pathway is inhibited to promote EndMT (37), the increased expression of EZH2, which further promotes endothelial cell hyperproliferation, leads to endothelial cell dysfunction (38).