Another example is the overexpression of Trx1 in the murine model of cardiac diseases, where its relevant role in essential processes for cardiac function has been demonstrated, participating in glycolysis, tricarboxylic acid cycle, beta-oxidation, the function of the mitochondrial permeability transition pore (mPTP), and the contractile apparatus of myofibrils. The gene discussed is TXN; the disease is heart disorder.