TXN and cancer: On the other side, the presence of TRX1 stimulates the angiogenesis induced by the vascular endothelial growth factor and, in some types of cancer, there is a diminution in the amount of the natural inhibitor of TRX1 (TXNIP), making the TRX1 unable to dissociate from ASK1 and hindering the cell to undergo apoptosis by stress [6,9].