SIRT2 and central nervous system cancer: Figure 1B shows the correlation between SIRT gene expression in TCGA gliomas. The ROC curve tests showed that SIRT2 (AUC = 0.811) and SIRT6 (AUC = 0.805) can effectively distinguish glioma samples from normal brain tissue samples (Figure 1C). Figure 1D shows SIRT gene expression in gliomas and normal brain tissues in the HPA database.