It was shown that the expression and activity of Beta-1,4-galactosyltransferase one correlated with the malignancy of various tumors, including hepatocellular carcinoma, breast cancer, glioblastoma, and lung cancer (Zhu et al., 2005; Choi et al., 2012; Villegas-Comonfort et al., 2012; Tang et al., 2013; Wang et al., 2020). This evidence concerns the gene B4GALT1 and hepatocellular carcinoma.