B4GALT1 and breast cancer: Tang et al. (2013) found that β1,4-galactosyltransferase one affects the growth and apoptosis of hepatocellular carcinoma cells by regulating EGFR. Estrogen and arachidonic acid have been reported to promote proliferation and cell adhesion of human breast cancer cells by inducing B4GALT1 expression (Choi et al., 2012; Villegas-Comonfort et al., 2012). In glioblastoma, B4GALT1 regulates apoptosis and autophagy, enhancing tumor proliferation, migration, and invasion (Wang et al., 2020).