Recent studies have shown that Tregs, an essential component of the acute myeloid leukemia (LAML) microenvironment, secretes IL-10 that interacts with IL-10 R on the surface of cancer cells and further activates the PI3K/AKT signaling pathway, promoting stemness of leukemic stem cells and the development of leukemia (B4GALT1u et al., 2021). Here, AKT1 is linked to leukemia.