Herein, we selected the LECs knocked out of ATG7 to abolish the autophagy process during oxidative stress, and conducted detailed analyses of RNA sequencing data from the Gene Expression Omnibus (GEO) database to explore the expression profiles of mRNAs and lncRNAs of LECs under the circumstance of oxidative stress and to try to construct the possible molecular network of ATG7-associated cataractogenic mechanisms, hoping to offer some clues to the studies regarding the prevention and/or treatment of cataracts. This evidence concerns the gene ATG7 and cataract.