In the 28 cases, a total of 46 different variants were detected in 15 known deafness genes, of which 21 (21/46, 45.7%) were novel from TRIOBP, MPZL2, MYO15A, PCDH15, LOXHD1, POU3F4, CDH23, COL11A2, and HARS2 genes. The gene discussed is LOXHD1; the disease is deafness.