HELLS and neoplasm: Among these genes, 11 driver genes (PGD, TF, ALOX12, ALOX15B, MAPK3, PEPB1, CDO1, CHAC1, LINC00472, PRKAA2, and YY1AP1) were downregulated in tumor tissues, and five suppressor genes (SLC7A11, HELLS, TP63, FADS2, and CA9) were upregulated.