CD274 and neoplasm: As shown in Figure 7C, the integrated area under the curve (AUC) of the CAF signature, tumor mutation burden (TMB) and combined expression of CD8, CD274, and Merck18 was 0.776, which was higher than the AUC of TMB (AUC = 0.571) as well as the AUC of the expression of immune checkpoints (AUC = 0.760).