As shown in Figure 7C, the integrated area under the curve (AUC) of the CAF signature, tumor mutation burden (TMB) and combined expression of CD8, CD274, and Merck18 was 0.776, which was higher than the AUC of TMB (AUC = 0.571) as well as the AUC of the expression of immune checkpoints (AUC = 0.760). The gene discussed is CD8A; the disease is neoplasm.