Among them, data scarcity that address AMPs and TLR4 interactions is clear and novel approaches for better understand such interaction must be performed.In addition to a better understanding of mechanism of action, it is vital to search for molecules that antagonize the uncontrolled inflammatory process, given the number of diseases that are aggravated in this process, such as rheumatoid arthritis, osteoarthritis, neurodegenerative diseases, autoimmune diseases, Guillain-Barre syndrome and psoriasis (Anwar et al., 2019; Cook et al., 2004). Here, TLR4 is linked to neurodegenerative disease.