As one of the members of the NAP1L protein family, NAP1L5 was identified as an imprinted gene in human liver malignancy and congenital heart diseases and an important regulator of translation activation during cardiomyocyte hypertrophy (Harada et al., 2002; Chang et al., 2021; Guo et al., 2021). Here, NAP1L5 is linked to congenital heart disease.