We further demonstrated that NAP1L5 also regulated the activity of GSK3B, a protein kinase that can phosphorylate Tau at most of the known AD sites, by phosphorylating GSK3B at Ser9, whose activity also involves in the Wnt/β-Catenin signaling pathway (Clevers and Nusse, 2012; Meffre et al., 2014; Nusse and Clevers, 2017). This evidence concerns the gene NAP1L5 and Alzheimer disease.