Herein, we found that AQP1, a key regulator or trigger of Wnt/β-Catenin signaling pathway involved in the pathogenesis of AD (Misawa et al., 2008; Ijaz et al., 2021; Park et al., 2021), was negatively correlated with NAP1L5 expression, indicating that AQP1 might involve in NAP1L5-mediated regulation of the Wnt/β-Catenin signaling pathway. The gene discussed is NAP1L5; the disease is Alzheimer disease.