ID2 and glioblastoma: According to studies, CBD downregulate the metastatic factor (ID1) and up-regulates the pro-differentiation factor (ID2), which results in a significant reduction in the invasion glioblastoma (GBM), inhibition of GBM dispersal ex vivo, and reduction in tumor growth and Id-1 expression in vivo (Soroceanu et al., 2013).