In addition, a phase I study testing vibostolimab (other anti-TIGIT) showed an ORR of 26% when combined with pembrolizumab in anti-PD-1/PD-L1-naive patients with NSCLC, but minimal efficacy in the anti-PD-1/PD-L1 refractory cohort (ORR 3%) (58). Here, CD274 is linked to non-small cell lung carcinoma.