The intracellular signaling pathways of LAG3 play a role in the regulation of immune cell function as the coexpression of LAG3 with other inhibitory molecules, including PD-1, TIGIT, TIM-3, 2B4, and CD160, inhibits the tumor immune microenvironment by accelerating T-cell exhaustion and blocking T-cell proliferation (63). Here, TIGIT is linked to neoplasm.