showed that interferon gamma (IFNγ) discharged from CD8 T cells reduced the expression of SLC7A11 and SLC3A2, inhibited the uptake of cystine by tumor cells, which in turn enhanced ferroptosis -specific lipid peroxidation in cancer cells, and increased ferroptosis contributed to the anti-tumor effect of immunotherapy (58). The gene discussed is CD8A; the disease is cancer.