Hong et al. found that TF was down-regulated in melanoma by comparing the GSEA databases, and their study showed that the lipidogen regulator Sterol-regulatory element binding proteins (SREBP2) could directly induce the transcription of the TF, thereby decreasing the intracellular iron pool, the activity of oxygen and lipid peroxidation, and inhibiting ferroptosis in cells. This evidence concerns the gene TF and melanoma.