LAMP2 is available in three isotypes: LAMP2A, LAMP2B and LAMP2C. Saha et al. showed that up-regulated LAMP2A reduced the oxidative modification of cellular proteins in breast cancer, and the inhibition of LAMP2A stimulated the accumulation of chaperone autophagy substrate GAPDH, AKT serine/threonine kinase 1 (AKT1) phosphorylation, ROS production and the induction apoptosis in breast cancer cells. Here, GAPDH is linked to breast cancer.