WNK2 and central nervous system cancer: 1-Methyl-3-isobutylxanthine is also known as 3-isobutyl-1-methylxanthine (IBMX). Lv et al. indicated that IBMX decreased the proliferation and invasion of glioma stem cells by activating the cAMP signaling pathway and inhibiting the mitogen-activated protein kinases (MAPK) signaling pathway.