NOS2 and breast cancer: found that 18β-glycyrrhetinic acid (GA) promoted the production of ROS and reactive nitrogen species (RNS) by activating inducible nitric oxide synthase (iNOS), and then suppressed the activity of GSH and GPX4 by deactivating nicotinamide adenine dinucleotide phosphate oxidase (NADPH), thereby aggravating lipid peroxidation and triggering ferroptosis in breast cancer cells (MDA-MB-231) (11).