GPX4 and breast cancer: used breast cancer cells (MDA-MB-231, SUM159, BT-574) and found that DMOCPTL directly bound to the glutathione peroxidase 4 (GPX4) to up-regulate early growth response 1 (EGR1) in TNBC cells, leading to apoptosis of mitochondrial mediator and further inhibiting breast tumor growth (9).