HMGB1 and breast cancer: As shown in Table 5, experimental studies have shown that CDKN2A, PSAT1, HMGB1, ELAVL1, and SLC7A11 were up-regulated in TNBC, ASNS and LAMP2 were up-regulated in breast cancer and CAV1 was down-regulated in breast cancer, and HELLS was up-regulated in other tumors.