Tumor samples from 4 patients who experienced disease control (2 PRs and 2 SDs by IRC assessment) with bintrafusp alfa had a median 32-fold higher expression of HMGA2 (q=4.34e-14 as computed by DESeq2) (34) than samples from patients who had PD (Figure 3A). The gene discussed is HMGA2; the disease is neoplasm.