Notably, HMGA2 expression was found to be associated with response to bintrafusp alfa only in the TNBC cohort, and not in any other expansion cohorts in NCT02517398, including biliary tract cancer, non-small cell lung cancer, and squamous cell carcinoma of the head and neck (Supplementary Figure 3). This evidence concerns the gene HMGA2 and squamous cell carcinoma.