Among these 12 prognostic crlncRNAs, the lncRNA of SNHG16 was upregulated in laryngeal squamous cell carcinoma tissues (LSCC) by regulating the miR-140-5p/NFAT5/Wnt/β-catenin pathway axis, which may possibly provide a novel method for HNSCC treatment. Here, NFAT5 is linked to laryngeal squamous cell carcinoma.