The potential advantages of TL-PSMA can be explained by the fact that SUVmax represents only the highest voxel value within a tumor lesion, namely the maximum metabolic activity, and PSMA-TV represents only the high metabolic volume within the tumor lesion, whereas TL-PSMA combines both metabolic activity and volume to reflect the tumor burden more comprehensively and confirming the previous finding of Im et al. The gene discussed is FOLH1; the disease is neoplasm.