Consistent with a pro-apoptotic function of MAP4K4 in ALS, specific inhibition of MAP4K4 with experimental Compound 29 (47) prevented motor neuron death and improved neurite integrity both by directly blocking JNK3-cJUN-mediated apoptosis and by activating FOXO1-mediated autophagy (48). The gene discussed is MAP4K4; the disease is amyotrophic lateral sclerosis.