MAP4K4 binds STRN4, a component of the STRIPAK complex. STRIPAK signaling activates the Hippo pathway via MAP4K4 on the one hand and promotes pro-invasive signaling via PKCθ on the other hand. Dysregulated STRIPK signaling is involved in cancer progression due to impaired Hippo tumor suppressor pathway activation and increased invasiveness. This evidence concerns the gene PRRT2 and cancer.