In adult patient-derived glioma cells, MAP4K4 is necessary for pro-metastatic functions (7), and in pediatric medulloblastoma cells, it promotes invasion induced by epidermal (EGF), hepatocyte (HGF) and basic fibroblast growth factor (bFGF) (6, 39, 62). The gene discussed is MAP4K4; the disease is central nervous system cancer.