HMGB3 can promote the production of reactive oxygen species (ROS) via specific Toll-like receptors (TLRs) on membranes (66), and can regulate cell cycle-induced tumorigenesis, thus promoting cancer cell proliferation and invasion by regulating signaling pathways including Wnt/β-catenin (67), MAPK (68), and Akt (69), enhancing cancer stem cell gene activity and promoting the malignant proliferation of cancer cells. The gene discussed is HMGB3; the disease is cancer.