BCL2 and cancer: In gastric adenocarcinoma cells, down-regulation of HMGB3 expression can dramatically suppress cancer cell proliferation, mostly through the induction of G0/G1 blockade in cancer cells, regulation of p53 and p21 signaling pathways, and downregulation of the ratio of anti-apoptotic factor Bcl-2/pro-apoptotic factor Bax (73).