We finally obtained ten key genes that are closely associated with the prognosis of DLBCL patients, including CXCL9, TIFAB, C3, VCVAM1, ZBE, D2, TIMD4, KLHL14, TNFRSF9, FCRL3 and PLEKHG1. Here, TIFAB is linked to diffuse large B-cell lymphoma.