ITGB3 and central nervous system cancer: CD49c, CD61 and CD34, are all hallmarks of tumor aggressiveness: CD49c, by cooperating with EGFR, has been shown to contribute in driving tumor cell motility and invasion especially in histone WT patient-derived cell lines (59); CD61 is one of the most widely studied members of the integrin family, involved in tumor progression (60, 61) while CD34 overexpression in glioma tissues was closely associated with higher WHO grade (III + IV) (62).