To further validate the important role of VLDLR in the outcome of breast cancer patients, we stratified the breast cancer patients based on the VLDLR expression level using a publicly available database (35–37) and found that elevated VLDLR expression was significantly associated with worse overall survival (Figure 6D and Supplementary Figure 7B), as well as relapse-free survival (Figure 6E). Here, VLDLR is linked to breast cancer.