In addition to the detection of a pathogenic CHEK2 variant in two cases with use of the 84-gene virtual WES panel, actionable variants were also detected in the lesser-known cancer-associated genes PTCH1 and KIT. PTCH is involved in the hereditary condition Nevoid basal cell carcinoma syndrome (NBCCS) or Gorlin syndrome (45, 46). Here, KIT is linked to nevoid basal cell carcinoma syndrome.