CHEK2 and cancer: In addition to the detection of a pathogenic CHEK2 variant in two cases with use of the 84-gene virtual WES panel, actionable variants were also detected in the lesser-known cancer-associated genes PTCH1 and KIT. PTCH is involved in the hereditary condition Nevoid basal cell carcinoma syndrome (NBCCS) or Gorlin syndrome (45, 46).