Detection of pathogenic variants with varying penetrance in the BRCA1 and BRCA2 genes are responsible for approximately two-thirds of hereditary breast and ovarian cancer, with cumulative risks ranging from 16–84% and 11–87% for BRCA2 and BRCA1, respectively, by age 80 years (7). Here, BRCA2 is linked to Hereditary breast and ovarian cancer syndrome.