RRBP1 and cancer: We also looked into the effect of CMs from the two-type cancer cells transduced with the shRNA/RRBP1 vector (shRRBP1) on the osteoblastic phenotype expression in MC3T3-E1 preosteoblastic cells, the effect of injection with the two-type cancer cells transduced with shRRBP1 into the tibia medullary cavity of nude mice on bone tissue, and the mechanism of RRBP1 responsible for modifying the osteoblastic phenotype expression associated with ER stress.