As shown by CCK-8 and colony formation, comparing with the control group, the growth rate of CRC cells was evidently inhibited after overexpressed HRK (Figures 4C, D) In addition, we also tested the ability of cell migration and invasion by Matrigel invasion assay, Matrigel-free transwell assay and Wound-healing assay. Here, HRK is linked to colorectal carcinoma.