NUCLEOLIN and neoplasm: constructed an autonomous DNA robot using DNA origami, which delivers thrombin specifically to tumor-associated blood vessels and induces intravascular thrombosis with a DNA aptamer outside that binds nucleolin (a protein specifically expressed on tumor-associated endothelial cells) and the blood coagulation protease thrombin in its cavity, resulting in tumor necrosis and inhibition of tumor growth, proposed a promising strategy for precise drug delivery and preoperative management in cancer therapy (Figure 2F) (52).