Similarly, it can inhibit the migration and induce the mobilization of malignant cells, which rely on CXCL12/CXCR4 interactions to colonize the BM, as demonstrated in human CLL-stroma co-cultures (101) and murine models of MM and CML (128, 129). The gene discussed is CXCL12; the disease is B-cell chronic lymphocytic leukemia.