CXCL12 and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, it can inhibit the migration and induce the mobilization of malignant cells, which rely on CXCL12/CXCR4 interactions to colonize the BM, as demonstrated in human CLL-stroma co-cultures (101) and murine models of MM and CML (128, 129).