KEGG pathway analysis showed that these 24 IRGs were mainly enriched in natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, NF-kappa B signaling pathway, Rap1 signaling pathway, B cell receptor signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, cytokine-cytokine receptor interaction, etc (Figure 7C). Here, CD274 is linked to cancer.