While the criterion of Restrictive/HFpEF Phenotype should include: (1) Exclusion of infiltrative heart disease by endomyocardial biopsy; (2) LVEF>50%, LVEDVI<97 mL/m2; and (3) E/e’ >15 or 8<E/e’ <15+LAVI>40 mL/m2 or 8<E/e’ <15+BNP>200 pg/mL or 8<E/e’ <15+atrial fibrillation or 8<E/e’<15+LVH (LVMI♀>122 g/m2; LVMI♂>149 g/m2). This evidence concerns the gene NPPB and heart disorder.