HDAC4 and heart failure: Figure 3F is showcasing normalized phosphorylated to total HDAC4 ratio. These observations are depicting the selective effects of Que to reduce pSer246-HDAC4 expression in Que-treated diabetic rats. The relative cardiac tissue expression of pro B-type natriuretic peptide (BNP), a significant marker of progressed heart failure, remained unaffected neither by diabetes or quercetin (Figure 3C). Representative Western blots are displayed in Figure 3G.